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JWH 412

Item No. 11971

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4-fluoro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-methanone
CAS Number
1364933-59-4
Molecular Formula
C24H22FNO
Formula Weight
359.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/ml
λmax
217, 317 nm
SMILES
O=C(C1=C2C=CC=CC2=C(F)C=C1)C3=CN(CCCCC)C4=C3C=CC=C4
InChi Code
InChI=1S/C24H22FNO/c1-2-3-8-15-26-16-21(19-11-6-7-12-23(19)26)24(27)20-13-14-22(25)18-10-5-4-9-17(18)20/h4-7,9-14,16H,2-3,8,15H2,1H3
InChi Key
HDWMKVHXWFNFQW-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    JWH 412 is a positional isomer of AM2201 (Item No. 10707) that was identified in the ‘herbal mixture’ XoXo.1 The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018.1 JWH 412 demonstrates Ki values of 7.2 and 3.2 nM at CB1 and peripheral CB2 receptors, respectively.2 This product is intended for research and forensic purposes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moosmann, B., Kneisel, S., Girreser, U., et al. Separation and structural characterization of the synthetic cannabinoids JWH-412 and 1-[(5-fluoropentyl)-1H-indol-3yl]-(4-methylnaphthalen-1-yl)methanone using GC-MS, NMR analysis and a flash chromatography system. Forensic Sci. Int. 220(1-3), e17-e22 (2012).

    2. Smith, V.J. Synthesis and pharmacology of N-alkyl-3-(halonaphthoyl)indoles. Doctor of Philosophy Chemistry, 1-179-179 (2008).