A dehydration product of PGE3
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Prostaglandin B3

Item No. 11990

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-oxo-15S-hydroxy-prosta-5Z,8(12),13E,17Z-tetraen-1-oic acid
CAS Number
36614-32-1
Synonyms
  • PGB3
Molecular Formula
C20H28O4
Formula Weight
332.4
Purity
≥97%
Formulation (Request formulation change)
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >75 mg/ml (from PGB2)DMSO: >50 mg/ml (from PGB2)Ethanol: >100 mg/ml (from PGB2)PBS pH 7.2: >2 mg/ml (from PGB2)
λmax
280 nm
SMILES
O=C1C(C/C=C\CCCC(O)=O)=C(/C=C/[C@@H](O)C/C=C\CC)CC1
InChi Code
InChI=1S/C20H28O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h3-4,6-7,12,14,17,21H,2,5,8-11,13,15H2,1H3,(H,23,24)/b6-3-,7-4-,14-12+/t17-/m0/s1
InChi Key
DQRGQQAJYRBDRP-UNBCGXALSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 µg

    $107

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    50 µg

    $176

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    100 µg

    $322

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    Product Description

    Prostaglandin B3 (PGB3) is a non-enzymatic dehydration product resulting from the treatment of Prostaglandin E3 (PGE3) with strong base. In a structure-activity binding study to determine the affinity of various prostaglandins to human PPARγ, PGB3 exhibited a Ki value greater than 1 mM.1 In contrast, PGB1 and PGB2 showed significantly higher affinity for PPARγ, with Ki values of 26 and 77 µM, respectively, the same assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ferry, G., Bruneau, V., Beauverger, P., et al. Binding of prostaglandins to human PPARγ: Tool assessment and new natural ligands. Eur. J. Pharmacol. 417(1-2), 77-89 (2001).