For immunochemical detection of the BLT1 receptor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BLT1 Receptor Monoclonal Antibody (Clone 7B1)

Item No. 120111

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • BLTR1
  • Leukotriene B4 Receptor 1
  • LTB4 Receptor 1
Immunogen
HeLa cells transfected with human BLT1
Clone Designation
7B1
Formulation (Request formulation change)
200 µg of protein G-purified monoclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide
Host
Mouse
Isotype
IgG2a
Applications
FC, IF, and IHC of frozen sections
Cross Reactivity
(+) BLT1 receptor(-) BLT2 receptor(-) CysLT1 receptor(-) CysLT2 receptor
Species Reactivity
(+) Human BLT1 receptor
UniProt Accession №
Q15722
Origin
Animal/Mouse
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 ea (200 µg)

    $347

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    The human BLT1 receptor is a G protein-coupled receptor that mediates the proinflammatory effects of leukotriene B4 (LTB4).1 Northern blotting reveals that the BLT1 receptor is highly expressed in leukocytes, U937 cells, and to a much lower extent in spleen and thymus.1 Sheep lung membranes have also been identified as a rich source for receptor isolation and purification.2 A second, low-affinity LTB4 receptor, BLT2, has also been cloned and characterized.3,4,5 Cayman Chemical’s BLT1 Receptor Monoclonal Antibody is a useful tool for the detection of human BLT1 by flow cytometry, immunofluorescence, and immunohistochemistry. The antibody does not cross react with the other leukotriene receptors (BLT2, CysLT1, or CysLT2) and does not work for Western blot analysis of BLT1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yokomizo, T., Izumi, T., Chang, K., et al. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387(6633), 620-624 (1997).

    2. Votta, B., Keefer, J., and Mong, S. Characterization of the soluble leukotriene B4 receptor from sheep lung membranes. Biochem. J. 270(1), 213-218 (1990).

    3. Yokomizo, T., Kato, K., Terawaki, K., et al. A second leukotriene B4 receptor, BLT2: A new therapeutic target in inflammation and immunological disorders. J. Exp. Med. 193(3), 421-431 (2000).

    4. Kamohara, M., Takasaki, J., Matsumoto, M., et al. Molecular cloning and characterization of another leukotriene B4 receptor. The Journal of Biological Chemisty 275(35), 27000-27004 (2000).

    5. Wang, S., Gustafson, E., Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. The Journal of Biological Chemisty 275(52), 40686-40694 (2000).

    Product Citations

    Hamlett, E.D., Hjorth, E., Ledreux, A., et al. RvE1 treatment prevents memory loss and neuringlammation in the Ts65Dn mouse model of Down syndrome. Glia (2020).

    Venerito, M., Helmke, C., Jechorek, D., et al. Leukotriene receptor expression in esophageal squamous cell cancer and non-transformed esophageal epithelium: a matched case control study. BMC Gastroenterol. 16(1), 85 (2016).