An NOP agonist
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MCOPPB (hydrochloride hydrate)

Item No. 12037

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole, trihydrochloride, hydrate
Molecular Formula
C26H40N4 • 3HCl [XH2O]
Formula Weight
536.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 10 mg/ml
λmax
252, 275, 283 nm
SMILES
CC1(CCCCCCC1)N(CC2)CCC2N3C4=CC=CC=C4N=C3[C@H]5CNCCC5.Cl.Cl.Cl.O
InChi Code
InChI=1S/C26H40N4.3ClH.H2O/c1-26(15-7-3-2-4-8-16-26)29-18-13-22(14-19-29)30-24-12-6-5-11-23(24)28-25(30)21-10-9-17-27-20-21;;;;/h5-6,11-12,21-22,27H,2-4,7-10,13-20H2,1H3;3*1H;1H2/t21-;;;;/m1..../s1
InChi Key
UQBVSGBDJOJHIP-YRTCJPGSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $132

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    10 mg

    $236

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    Product Description

    The nociceptin/orphanin FQ peptide (NOP, ORL1, or OP4) receptor is a member of the opioid family of receptors that integrates the emotional components of anxiety, fear, and stress. MCOPPB is a potent agonist for the NOP receptor (pKi = 10.1, EC50 = 0.39 nM) with 12-, 270-, and >1,000-fold selectivity over the μ-, κ-, and δ-opioid receptors.1,2 In rodents, MCOPPB at 10 mg/kg, p.o. produces potent anxiolytic effects, without inhibiting memory or motor function or inducing sedative side effects.1 This product is intended for research purposes only.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hirao, A., Imai, A., Sugie, Y., et al. Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an anxiolytic agent. J. Pharmacol. Sci. 106, 361-368 (2008).

    2. Hayashi, S., Hirao, A., Imai, A., et al. Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug. J. Med. Chem. 52, 610-625 (2009).