For immunochemical detection of the CysLT1 receptor
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CysLT1 Receptor Polyclonal Antibody

Item No. 120500

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cysteinyl Leukotriene Receptor 1
Immunogen
Synthetic peptide from the C-terminal region of human CysLT1
Formulation (Request formulation change)
500 μl peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
WB
Species Reactivity
(+) Human(+) Murine
UniProt Accession №
Q9Y271
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    The cysteinyl leukotrienes (CysLTs; LTC4, LTD4, and LTE4) contract airway and pulmonary vascular smooth muscle, increase vascular permeability, and stimulate mucus secretion, thereby playing a major role in asthma.1,2,3,4 LTC4, LTD4, and LTE4 mediate their actions via at least two receptors designated CysLT1 and CysLT2.1 Cloning of the human CysLT1 receptor reveals it is a 337 amino acid protein with a calculated molecular mass of 38,549.5 The rank order of binding for leukotrienes to the cloned receptor, as determined using a radioligand binding assay, is LTD4 >> LTC4 = LTE4 >> LTB4.5 The mRNA for the human CysLT1 receptor is expressed in spleen and peripheral blood leukocytes with smaller amounts in lung, placenta, and small intestine. Immunohistochemical studies reveal the receptor is expressed on eosinophils, mast cells, macrophages, neutrophils, and vascular endothelial cells in the nasal mucosa.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gorenne, I., Norel, X., and Brink, C. Cysteinyl leukotriene receptors in the human lung: What’s new? Trends Pharmacol. Sci. 17(10), 342-343 (1996).

    2. Dahlén, S.E., Hansson, G., Hedqvist, P., et al. Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. Proc. Natl. Acad. Sci. USA 80(6), 1712-1716 (1983).

    3. Busse, W.W. The role of leukotrienes in asthma and allergic rhinitis. Clin. Exp. Allergy 26(8), 868-879 (1996).

    4. Hedqvist, P., Dahlén, S.E., Gustafsson, L., et al. Biological profile of leukotrienes C4 and D4. Acta Physiol. Scand. 110(3), 331-333 (1980).

    5. Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399(6738), 789-793 (1999).

    6. Shirasaki, H., Kanaizumi, E., Watanabe, K., et al. Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. Clin. Exp. Allergy 32(7), 1007-1012 (2002).

    Product Citations

    Nielsen, C.K., Campbell, J.I., Ohd, J.F., et al. A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. Cancer Res. 65(3), 732-742 (2005).