The less active C-8 diastereomer of BW 245C
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BW 246C

Item No. 12055

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4R)-rel-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid
CAS Number
65705-83-1
Synonyms
  • 8-epi BW 245C
Molecular Formula
C19H32N2O5
Formula Weight
368.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 2.19 mg/ml
SMILES
[H]N(C(N(CCC(O)C1CCCCC1)[C@@H]2CCCCCCC(O)=O)=O)C2=O
InChi Code
InChI=1S/C19H32N2O5/c22-16(14-8-4-3-5-9-14)12-13-21-15(18(25)20-19(21)26)10-6-1-2-7-11-17(23)24/h14-16,22H,1-13H2,(H,23,24)(H,20,25,26)/t15-,16?/m1/s1
InChi Key
ZIDQIOZJEJFMOH-AAFJCEBUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $61

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    5 mg

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    10 mg

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    Product Description

    BW 246C (Item No. 12055) is the less active C-8 diastereomer of the DP receptor agonist BW 245C.1,2 The activity of BW 245C is 70-fold greater than that of BW 246C.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. The Journal of Biological Chemisty 270(32), 18910-18916 (1995).

    2. Town, M.H., Casals-Stenzel, J., and Schillinger, E. Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors. Prostaglandins 25(1), 13-28 (1983).

    3. Caldwell, A.G., Harris, C.J., Stepney, R., et al. Heterocyclic prostaglandin analogues. Part 2. Hydantoins and other imidazole analogues. J. Chem. Soc. Perkin 1 495-505 (1980).