A biochemical tool to screen for immune disorders
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D-Neopterin

Item No. 12057

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-6-[1S,2R,3-trihydroxypropyl]-4(3H)-pteridinone
CAS Number
2009-64-5
Molecular Formula
C9H11N5O4
Formula Weight
253.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.3 mg/mlDMSO: 1 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
215, 235, 275, 345 nm
SMILES
O=C1C2=NC([C@H](O)[C@H](O)CO)=CNC2=NC(N)=N1
InChi Code
InChI=1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6+/m1/s1
InChi Key
BMQYVXCPAOLZOK-XINAWCOVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    Neopterin is a pyrazino-pyrimidine compound derived from GTP that represents an intermediate product in the synthetic pathway of biopterin and is an essential cofactor in neurotransmitter synthesis.1 Neopterin is released from macrophages upon immune stimulation with interferon-γ from activated T cells.2 It is routinely used as a biochemical tool to screen for and monitor the progression of certain diseases accompanied by hyperimmune stimulation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shen, R., Alam, A., and Zhang, Y. Inhibition of GTP cyclohydrolase I by pterins. Biochim. Biophys. Acta 965(1), 9-15 (1988).

    2. Huber, C., Batchelor, J.R., Fuchs, D., et al. Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. J. Exp. Med. 160, 310-316 (1984).