A bioactive saponin from Astragalus
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Astragaloside IV

Item No. 12069

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,6α,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl, β-D-glucopyranoside
CAS Number
84687-43-4
Synonyms
  • AS-IV
  • AST-IV
Molecular Formula
C41H68O14
Formula Weight
785.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
O[C@H]1C[C@@]([C@]([C@@]1([H])[C@@]2(O[C@H](C(C)(O)C)CC2)C)(C)CC3)(C)[C@@](C[C@H](O[C@]4([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@]5([H])C6(C)C)([H])[C@@]73[C@]5(CC[C@@H]6O[C@]8([H])OC[C@@H](O)[C@H](O)[C@H]8O)C7
InChi Code
InChI=1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24
InChi Key
QMNWISYXSJWHRY-YLNUDOOFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 µM; LC50 = 865 µM).2 It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems.1,3 In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ren, S., Zhang, H., Mu, Y., et al. Pharmacological effects of Astragaloside IV: A literature review. J. Tradit. Chin. Med. 33(3), 413-416 (2013).

    2. Shang, L., Qu, Z., Sun, L., et al. Astragaloside IV inhibits adenovirus replication and apoptosis in A549 cells in vitro. J. Pharm. Pharmacol. 63(5), 688-694 (2011).

    3. Li, L., Hou, X., Xu, R., et al. Research review on the pharmacological effects of astragaloside IV. Fundam. Clin. Pharmacol. 31(1), 17-36 (2017).

    4. Zhang, W.-D., Chen, H., Zhang, C., et al. Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro. Planta Med. 72(1), 4-8 (2006).