A stable PGD2 synthetic analog
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15(S)-15-methyl Prostaglandin D2

Item No. 12730

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,15S-dihydroxy-11-oxo-15-methyl-prosta-5Z,13E-dien-1-oic acid
CAS Number
85280-90-6
Synonyms
  • 15(S)-15-methyl PGD2
Molecular Formula
C21H34O5
Formula Weight
366.5
Purity
≥95%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/mlDMSO: >50 mg/mlEthanol: >75 mg/mlPBS (pH 7.2): >5 mg/ml
SMILES
O=C1[C@H](/C=C/[C@@](C)(O)CCCCC)[C@@H](C/C=C\CCCC(O)=O)[C@@H](O)C1
InChi Code
InChI=1S/C21H34O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-18,22,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5-,14-12+/t16-,17-,18+,21+/m1/s1
InChi Key
CTXLUMAOXBULOZ-QEQARHSSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $81

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    1 mg

    $152

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    Product Description

    15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 (Item No. 12010). In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation.1 It also exhibits strong antifertility activity in hamsters (200-fold more potent than PGD2).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J. Med. Chem. 26(6), 790-799 (1983).