A stable PGD2 analog
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16,16-dimethyl Prostaglandin D2

Item No. 12750

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,15S-dihydroxy-16,16-dimethyl-11-oxo-prosta-5Z,13E-dien-1-oic acid
CAS Number
64072-59-9
Synonyms
  • 16,16-dimethyl PGD2
Molecular Formula
C22H36O5
Formula Weight
380.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/mlDMSO: >50 mg/mlEthanol: >75 mg/mlPBS pH 7.2: >5 mg/ml
SMILES
O=C1[C@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@@H](C/C=C\CCCC(O)=O)[C@@H](O)C1
InChi Code
InChI=1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-18,20,23,25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,18+,20-/m1/s1
InChi Key
ZEMOZGYCFBTCMC-MBNOUSKYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $59

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    1 mg

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    5 mg

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    10 mg

    $768

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    Product Description

    16,16-dimethyl PGD2 is a metabolically stable synthetic analog of PGD2. It enhances ADP-induced human platelet aggregation and increases systemic blood pressure in rats.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J. Med. Chem. 26(6), 790-799 (1983).

    Product Citations

    Gomez-Abellan, V., Montero, J., Lopez-Munoz, A., et al. Professional phagocytic granulocyte-derived PGD2 regulates the rsolution of inflammation in fish. Develop. Comp. Immunol. 52(2), 182-191 (2015).