An inhibitor of platelet aggregation
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Prostaglandin D3

Item No. 12990

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,15S-dihydroxy-11-oxo-prosta-5Z,13E,17Z-trien-1-oic acid
CAS Number
71902-47-1
Synonyms
  • PGD3
Molecular Formula
C20H30O5
Formula Weight
350.5
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/mlDMSO: >50 mg/mlEthanol: >75 mg/mlPBS (pH 7.2): >5 mg/ml
SMILES
O[C@@H](C1)[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C/C=C\CC)C1=O
InChi Code
InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
InChi Key
ANOICLBSJIMQTA-WXGBOJPQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $72

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    50 µg

    $108

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    100 µg

    $186

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    Product Description

    Prostaglandin D3 (PGD3) is produced by the metabolism of EPA via the COX pathway.1 It is equipotent to PGD2 (Item No. 12010) in decreasing systemic blood pressure in rats and in decreasing intraocular pressure in rabbits.2,3,4 However, it is 3-5 times more potent than PGD2 in the inhibition of ADP-induced human platelet aggregation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kulkarni, P.S., Kaufman, P.L., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. J. Ocul. Pharmacol. 3(4), 349-356 (1987).

    2. Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J. Med. Chem. 26(6), 790-799 (1983).

    3. Goh, Y., Nakajima, M., Azuma, I., et al. Effects of prostaglandin D2 and its analogues on intraocular pressure in rabbits. Jpn. J. Ophthalmol. 32(4), 471-480 (1988).

    4. Kulkarni, P.S., and Srinivasan, B.D. Prostaglandins E3 and D3 lower intraocular pressure. Invest. Ophthalmol. Vis. Sci. 26(8), 1178-1182 (1985).

    Product Citations

    Wu, Z., Xiao, H., Rao, D., et al. Analytical strategy for oxylipin annotation by combining chemical derivatization-based retention index algorithm and feature tandem mass spectrometric fragmentation as a biomarker discovery tool. Anal. Chem. 95(43), 15933-15942 (2023).

    Hartling, I., Cremonesi, A., Osuna, E., et al. Quantitative profiling of inflammatory and pro-resolving lipid mediators in human adolescents and mouse plasma using UHPLC-MS/MS. Clin. Chem. Lab. Med. 59(11), 1811-1823 (2021).

    Sasaki, A., Fukuda, H., Shiida, N., et al. Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS. Anal. Bioanal. Chem. 407(6), 1625-1639 (2015).