Protein cross-linking agent
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Product Categories

Product Type

Biochemicals

Research Area

Disuccinimidyl Suberate

Item No. 13008

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
octanedioic acid, 1,8-bis(2,5-dioxo-1-pyrrolidinyl)ester
CAS Number
68528-80-3
Synonyms
  • DSS
  • NSC 340008
Molecular Formula
C16H20N2O8
Formula Weight
368.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml
SMILES
O=C(CCCCCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O
InChi Code
InChI=1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2
InChi Key
ZWIBGKZDAWNIFC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $13

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    100 mg

    $20

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    250 mg

    $44

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    500 mg

    $77

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    Product Description

    Disuccinimidyl suberate (DSS) is a bifunctional cross-linking reagent which contains two N-hydroxysuccinimide esters that are reactive toward primary amines. DSS is membrane-permeable and is commonly used to cross-link proteins in intact cells.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hétu, P.O., Ouellet, M., Falgueyret, J.P., et al. Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E2 synthase-1. Arch. Biochem. Biophys. 477, 155-162 (2008).

    2. Ding, H., and Johnson, G.V.W. New application of ß-galactosidase complementation to monitor tau self-association. J. Neurochem. 106, 1545-1551 (2008).