An endothelial lipase inhibitor
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GSK264220A

Item No. 13009

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenyl-urea
CAS Number
685506-42-7
Molecular Formula
C17H21N3O4S
Formula Weight
363.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 0.5 mg/ml
λmax
246 nm
SMILES
O=C(Nc1ccccc1)Nc1cc(oc1C)S(=O)(=O)N1CCCCC1
InChi Code
InChI=1S/C17H21N3O4S/c1-13-15(19-17(21)18-14-8-4-2-5-9-14)12-16(24-13)25(22,23)20-10-6-3-7-11-20/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3,(H2,18,19,21)
InChi Key
LVOVQRPAMXCXTM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $169

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    25 mg

    $378

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    Product Description

    Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as substrate. GSK264220A is a potent inhibitor of endothelial lipase (IC50 = 16 nM).1 Levels of HDL cholesterol are inversely correlated with endothelial lipase protein activity. Therefore, inhibition of endothelial lipase by compounds like GSK264220A may be expected to increase HDL levels and potentially decrease the risk of cardiovascular disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Keller, P.M., Rust, T., Murphy, D.J., et al. A high-throughput screen for endothelial lipase using HDL as substrate. J. Biomol. Screen. 13(6), 468-475 (2008).