The ethanolamine-amide analog of PGE1
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Prostaglandin E1 Ethanolamide

Item No. 13012

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11α,15S-dihydroxy-N-(2-hydroxyethyl)-9-oxo-prost-13E-en-1-amide
CAS Number
210976-81-1
Synonyms
  • Alprostadil Ethanolamide
  • PGE1-EA
Molecular Formula
C22H39NO5
Formula Weight
397.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 50 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/mlIsotonic Saline: 5 mg/ml
SMILES
O=C1[C@H](CCCCCCC(NCCO)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1
InChi Code
InChI=1S/C22H39NO5/c1-2-3-6-9-17(25)12-13-19-18(20(26)16-21(19)27)10-7-4-5-8-11-22(28)23-14-15-24/h12-13,17-19,21,24-25,27H,2-11,14-16H2,1H3,(H,23,28)/b13-12+/t17-,18+,19+,21+/m0/s1
InChi Key
HLQFDRCTTQBTCE-RCDOCOITSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Prostaglandin E1 ethanolamide (PGE1-EA) is the ethanolamine-amide analog of PGE1. Conversion of AEA, the ethanolamide of arachidonic acid, to PGE2-EA has been demonstrated in vitro.1,2 It is not established whether this conversion occurs in whole animals, nor has the pharmacology of the resultant prostaglandin ethanolamides been rigorously studied.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, M., Ives, D., and Ramesha, C.S. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. The Journal of Biological Chemisty 272(34), 21181-21186 (1997).

    2. Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. The Journal of Biological Chemisty 277(47), 44877-44885 (2002).