Inhibitor of furin
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Naphthofluorescein

Item No. 13055

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,11-dihydroxy-spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one
CAS Number
61419-02-1
Synonyms
  • CCG 8295
Molecular Formula
C28H16O5
Formula Weight
432.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7) (1:10): 0.09 mg/mlDMSO: 3 mg/mlEthanol: 2 mg/ml
λmax
233, 255 nm
SMILES
O=C(C1=C2C=CC=C1)OC32C4=CC=C5C(C=CC(O)=C5)=C4OC6=C3C=CC7=C6C=CC(O)=C7
InChi Code
InChI=1S/C28H16O5/c29-17-7-9-19-15(13-17)5-11-23-25(19)32-26-20-10-8-18(30)14-16(20)6-12-24(26)28(23)22-4-2-1-3-21(22)27(31)33-28/h1-14,29-30H
InChi Key
IXQIUDNVFVTQLJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM).1 It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP.1 This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP.1 Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080.1 The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coppola, J.M., Bhojani, M.S., Ross, B.D., et al. A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness. Neoplasia 10(4), 363-370 (2008).