Activator of ACE2
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Resorcinolnaphthalein

Item No. 13082

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3',6'-dihydroxy-spiro[1H,3H-naphtho[1,8-cd]pyran-1,9'-[9H]xanthen-3-one
CAS Number
41307-63-5
Synonyms
  • NSC 354317
Molecular Formula
C24H14O5
Formula Weight
382.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
216, 278 nm
SMILES
Oc1ccc2c(c1)Oc1cc(O)ccc1C12OC(=O)c2cccc3cccc1c23
InChi Code
InChI=1S/C24H14O5/c25-14-7-9-17-20(11-14)28-21-12-15(26)8-10-18(21)24(17)19-6-2-4-13-3-1-5-16(22(13)19)23(27)29-24/h1-12,25-26H
InChi Key
FTUOFHGOGJGQAB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $24

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    10 mg

    $42

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    50 mg

    $173

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    100 mg

    $302

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    Product Description

    Resorcinolnaphthalein increases the activity of ACE2 in vitro (EC50 = 19.5 μM).1 Activation of ACE2 in rats produces a decrease in blood pressure and improvement in cardiac function. In spontaneously hypertensive rats it produces a reversal of myocardial, perivascular, and renal fibrosis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Prada, J.A.H., Ferreira, A.J., Katovich, M.J., et al. Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension 51, 1312-1317 (2008).