Inducer of autophagy in renal cell carcinoma cells
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STF-62247

Item No. 13084

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
CAS Number
315702-99-9
Molecular Formula
C15H13N3S
Formula Weight
267.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.2 mg/ml
λmax
246, 296 nm
SMILES
Cc1cccc(c1)Nc1scc(n1)c1ccncc1
InChi Code
InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
InChi Key
KATNUHQNJGNLPW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $66

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    10 mg

    $118

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    25 mg

    $278

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    50 mg

    $489

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    Cayman Chemical
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    Product Description

    STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM).1 It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice.1,2,3 STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 μM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Turcotte, S., Sutphin, P.D., and Giaccia, A.J. Targeting therapy for the loss of von Hippel-Lindau in renal cell carcinoma a novel molecule that induces autophagic cell death. Autophagy 4(7), 944-946 (2008).

    2. Turcotte, S., Chan, D.A., Sutphin, P.D., et al. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell 14(1), 90-102 (2008).

    3. Chan, D.A., and Giaccia, A.J. Targeting cancer cells by synthetic lethality autophagy and VHL in cancer therapeutics. Cell Cycle 7(19), 2987-2990 (2008).

    Product Citations

    Selka, A., Doiron, J.A., Lyons, P.A., et al. Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells. Eur. J. Med. Chem. 179, 347-357 (2019).