A potent inducer of apoptosis and growth inhibition

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MPI-0441138

Name: MPI-0441138
Brand: -

Item No. 13098

MPI-0441138 (EP128265, CAS Number: 827030-33-1)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

2-chloro-N-(4-methoxyphenyl)-N-methyl-4-quinazolinamine

CAS Number

827030-33-1

Synonyms

EP128265

Molecular Formula

C₁₆H₁₄ClN₃O

Formula Weight

299.8

Purity

≥98%

Formulation (Request formulation change)

A crystalline solid

Solubility(Learn about Variance in Solubility)

DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 5 mg/ml

λ_max

215, 383, 336 nm

SMILES

ClC(N=C1N(C2=CC=C(OC)C=C2)C)=NC3=C1C=CC=C3

InChi Code

InChI=1S/C16H14ClN3O/c1-20(11-7-9-12(21-2)10-8-11)15-13-5-3-4-6-14(13)18-16(17)19-15/h3-10H,1-2H3

InChi Key

CIPVUQSDDVFBPO-UHFFFAOYSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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1 mg

$41

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5 mg

$178

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10 mg

$312

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25 mg

$680

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Product Description

MPI-0441138 is a potent inducer of apoptosis and growth inhibition (EC₅₀ = 2 nM for both processes, based on caspase-3 activation and total cellular ATP, respectively) in T47D and HCT116 cells.^1,2 MPI-0441138 has excellent blood brain barrier penetration and is effective in mouse xenograft cancer models.^1,2

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Sirisoma, N., Kasibhatla, S., Pervin, A., et al. Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity. J. Med. Chem. 51, 4771-4779 (2008).

2. Sirisoma, N., Pervin, A., Zhang, H., et al. Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J. Med. Chem. 52(8), 2341-2351 (2009).

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