A DNA-crosslinking agent
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Labeled Version(s)
34506Carboplatin-d4
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
DNA Damage and Repair

Carboplatin

Item No. 13112

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2-)-κO,κO'']-platinum
CAS Number
41575-94-4
Synonyms
  • CBDCA
  • CDDCA
  • cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
  • NSC 201345
  • NSC 241240
Molecular Formula
C6H12N2O4Pt
Formula Weight
371.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
SMILES
O=C([O-][Pt+2]1([NH3])[NH3])C2(CCC2)C([O-]1)=O
InChi Code
InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2
InChi Key
OLESAACUTLOWQZ-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    Cayman Chemical
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    Product Description

    Carboplatin is a platinum-containing DNA-crosslinking agent.1 It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks when used at concentrations of 200 and 300 µM. It inhibits the proliferation of GLC-4 small cell lung carcinoma and A2780 and SKOV3 ovarian cancer cells (IC50s = 22.7, 0.5, and 10.2 µM, respectively).2,3 Carboplatin reduces tumor growth in an ADJ/PC6 murine plasmacytoma model (ED90 = 0.6 mg/kg, i.p.).4 Formulations containing carboplatin have been used in the treatment of ovarian cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Micetich, K.C., Barnes, D., and Erickson, L.C. A comparative study of the cytotoxicity and DNA-damaging effects of cis-(diammino)(1,1-cyclobutanedicarboxylato)-platinum(II) and cis-diamminedichloroplatinum(II) on L1210 cells. Cancer Res. 45(9), 4043-4047 (1985).

    2. Groen, H.J., Sleijfer, S., Meijer, C., et al. Carboplatin- and cisplatin-induced potentiation of moderate-dose radiation cytotoxicity in human lung cancer cell lines. Br. J. Cancer 72(6), 1406-1411 (1995).

    3. Al-Eisawi, Z., Beale, P., Chan, C., et al. Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models. J. Ovarian Res. 6(1), 78 (2013).

    4. Kelland, L.R., Abel, G., McKeage, M.J., et al. Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): An orally active platinum drug. Cancer Res. 53(11), 2581-2586 (1993).