An antiviral agent and active metabolite of brincidofovir
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Pro-drug Form(s)
35062Brincidofovir
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Cidofovir

Item No. 13113

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-phosphonic acid
CAS Number
113852-37-2
Synonyms
  • GS-0504
  • (S)-HPMPC
  • (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
Molecular Formula
C8H14N3O6P
Formula Weight
279.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 2 mg/ml
SMILES
NC(C=CN1C[C@H](OCP(O)(O)=O)CO)=NC1=O
InChi Code
InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
InChi Key
VWFCHDSQECPREK-LURJTMIESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $41

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    50 mg

    $72

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    100 mg

    $103

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    Product Description

    Cidofovir is an acyclic nucleoside phosphonate antiviral agent and an active metabolite of brincidofovir (Item No. 35062).1 It is formed from brincidofovir in MRC-5 human lung fibroblasts. Cidofovir inhibits CMV DNA synthesis in a cell-free assay, as well as replication of two CMV strains in plaque formation assays (IC50s = 0.1 and 0.07 µg/ml for Davis and AD-169 strains, respectively).2,3 It decreases mortality in mouse models of cowpox or vaccinia virus infections when administered at a dose of 15 mg/kg.4 Formulations containing cidofovir have been used in the treatment of CMV retinitis in patients with AIDS.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aldern, K.A., Ciesla, S.L., Winegarden, K.L., et al. Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-14C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism. Mol. Pharmacol. 63(3), 678-681 (2003).

    2. Xiong, X., Smith, J.L., and Chen, M.S. Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation. Antimicrob. Agents Chemother. 41(3), 594-599 (1997).

    3. Snoeck, R., Sakuma, T., De Clercq, E., et al. (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrob. Agents Chemother. 32(12), 1839-1844 (1988).

    4. Quenelle, D.C., Buller, R.M.L., Parker, S., et al. Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice. Antimicrob. Agents Chemother. 51(2), 689-695 (2007).