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Product Type

Biochemicals

Research Area

Cancer

Farnesyl Thiosalicylic Acid Amide

Item No. 13175

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]thio]-benzamide
CAS Number
1092521-74-8
Synonyms
  • FTS Amide
  • Salirasib Amide
Molecular Formula
C22H31NOS
Formula Weight
357.6
Purity
≥96%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/ml
SMILES
C\C(CC/C=C(CC/C=C(C)\C)\C)=C/CSC1=C(C(N)=O)C=CC=C1
InChi Code
InChI=1S/C22H31NOS/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6,9,11,13-15H,7-8,10,12,16H2,1-4H3,(H2,23,24)/b18-11+,19-15+
InChi Key
GZTMFRUGZMZCRD-CFBAGHHKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $21

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    5 mg

    $86

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    10 mg

    $152

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    50 mg

    $655

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    Cayman Chemical
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    Product Description

    Farnesyl thiosalicylic acid (FTS) amide is an FTS derivative with an amide added to the carboxyl group. FTS amide inhibits the growth of PANC-1 and U87 tumor cells with IC50 values of 20 and 10 µM, respectively, a relatively higher potency compared to that of FTS (IC50s = 35 and 50 µM, respectively).1 Treatment of nude mice bearing either U87 glioblastoma or PANC-1 tumors with 100 mg/kg FTS amide twice daily for four days inhibits tumor growth by at least 50% of controls.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goldberg, L., Haklai, R., Bauer, V., et al. New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: Farnesylthiosalicylamide inhibits tumor growth in nude mice models. J. Med. Chem. 52, 197-205 (2009).