A selective iNOS inhibitor
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BYK 191023 (hydrochloride)

Item No. 13177

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-(4-methoxy-2-pyridinyl)ethyl]-3H-imidazo[4,5-b]pyridine, dihydrochloride
CAS Number
1216722-25-6
Molecular Formula
C14H14N4O • 2HCl
Formula Weight
327.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: 100 mM
SMILES
COC1=CC=NC(CCC2=NC3=NC=CC=C3N2)=C1.Cl.Cl
InChi Code
InChI=1S/C14H14N4O.2ClH/c1-19-11-6-8-15-10(9-11)4-5-13-17-12-3-2-7-16-14(12)18-13;;/h2-3,6-9H,4-5H2,1H3,(H,16,17,18);2*1H
InChi Key
ZVNITETZYOKESF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    BYK 191023 is an L-arginine competitive and selective inhibitor of inducible nitric oxide synthase (iNOS) with IC50 values of 0.086, 17, and 162 μM for human recombinant iNOS, nNOS, and eNOS, respectively.1 It also inhibits murine recombinant iNOS (IC50 = 95 nM). BYK 191023 inhibits iNOS-induced nitrite generation in RMC, RAW, and HEK293 cells (IC50s = 33, 3.1, and 13 μM, respectively). In vivo, BYK 191023 suppresses LPS-induced increases in plasma nitrate and nitrite levels in rats (ED50 = 14.9 μmol/kg per hour).2 It prevents development of delayed hypotension in a rat model of LPS-induced endotoxemia when administered at a dose of 50 μmol/kg per hour. BYK 191023 also increases mean arterial pressure and renal blood flow in a sheep model of septic shock.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Strub, A., Ulrich, W.R., Hesslinger, C., et al. The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase. Mol. Pharmacol. 69(1), 328-337 (2006).

    2. Lehner, M.D., Marx, D., Boer, R., et al. In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase. J. Pharmacol. Exp. Ther. 317(1), 181-187 (2006).

    3. Su, F., Huang, H., Akieda, K., et al. Effects of a selective iNOS inhibitor versus norepinephrine in the treatment of septic shock. Shock 34(3), 243-249 (2010).