A selective iPLA2 inhibitor
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FKGK 11

Item No. 13179

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1,1,2,2-pentafluoro-7-phenyl-3-heptanone
CAS Number
1071000-98-0
Molecular Formula
C13H13F5O
Formula Weight
280.2
Purity
≥98%
Formulation
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
O=C(C(F)(F)C(F)(F)F)CCCCC1=CC=CC=C1
InChi Code
InChI=1S/C13H13F5O/c14-12(15,13(16,17)18)11(19)9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2
InChi Key
ROPVXAWEVYWEQY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $43

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    1 mg

    $77

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    5 mg

    $258

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    10 mg

    $429

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    Product Description

    FKGK 11 is a selective inhibitor of iPLA2 that demonstrates an XI(50) value of 0.0073, where XI(50) equals the mole fraction of FKGK 11 in the total substrate interface required to inhibit iPLA2 by 50%.1 In comparison, mole fractions as high as 0.091 do not inhibit cPLA2 activity and cause only slight inhibition of sPLA2.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baskakis, C., Magrioti, V., Cotton, N., et al. Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J. Med. Chem. 51(24), 8027-8037 (2008).