A mono-oxygenation product of DHA
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17(S)-HpDHA

Item No. 13185

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17S-hydroperoxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid
CAS Number
123673-33-6
Synonyms
  • 17(S)-hydroperoxy Docosahexaenoic Acid
  • 17(S)-HpDoHE
Molecular Formula
C22H32O4
Formula Weight
360.5
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: MiscibleDMSO: MiscibleEthanol: MisciblePBS (pH 7.2): 0.8 mg/ml
SMILES
CC\C=C/C[C@H](OO)/C=C/C=C\C\C=C/C\C=C/C\C=C/CCC(O)=O
InChi Code
InChI=1S/C22H32O4/c1-2-3-15-18-21(26-25)19-16-13-11-9-7-5-4-6-8-10-12-14-17-20-22(23)24/h3,5-8,11-16,19,21,25H,2,4,9-10,17-18,20H2,1H3,(H,23,24)/b7-5-,8-6-,13-11-,14-12-,15-3-,19-16+
InChi Key
BNHQALRBDJVUQB-VIIQGJSXSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $146

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    50 µg

    $277

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    100 µg

    $523

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    Product Description

    17(S)-HpDHA is a mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, human glial cells, and mouse brain.1 17(S)-HpDHA is generally reduced to 17(S)-HDHA (Item No. 10009799), a compound that serves as a precursor to 17(S)-resolvins. 17(S)-HDHA has been shown to inhibit TNF-α-induced interleukin-1β expression in human glioma cells and inhibit TNF-α-induced leukocyte trafficking to the murine air pouch.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. The Journal of Biological Chemisty 278(17), 14677-14687 (2003).