Potent antineoplastic agent
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Isomer(s)
10188trans-trismethoxy Resveratrol
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cis-trismethoxy Resveratrol

Item No. 13199

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dimethoxy-5-[(1Z)-2-(4-methoxyphenyl)ethenyl]-benzene
CAS Number
94608-23-8
Synonyms
  • cis-Trimethoxy Stilbene
Molecular Formula
C17H18O3
Formula Weight
270.3
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/ml
λmax
217, 285 nm
SMILES
COC1=CC(/C=C\C2=CC=C(OC)C=C2)=CC(OC)=C1
InChi Code
InChI=1S/C17H18O3/c1-18-15-8-6-13(7-9-15)4-5-14-10-16(19-2)12-17(11-14)20-3/h4-12H,1-3H3/b5-4-
InChi Key
GDHNBPHYVRHYCC-PLNGDYQASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $19

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    50 mg

    $74

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    100 mg

    $130

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    500 mg

    $561

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    Product Description

    cis-trismethoxy Resveratrol is a potent anti-mitotic drug that is 100-fold more active than resveratrol at inhibiting the growth of human colon cancer Caco-2 cells.1 It inhibits tubulin polymerization in a dose-dependent manner (IC50 = 4 μM) and inhibits enzymes involved in the synthesis of the polyamines, putrescine, and spermidine.1,2 trans-trismethoxy Resveratrol has superior pharmacokinetic characteristics when compared with resveratrol, including greater plasma exposure, longer elimination half-life, and lower clearance.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schneider, Y., Chabert, P., Stutzmann, J., et al. Resveratrol analog (Z)-3,5,4'-trimethoxystilbene is a potent anti-mitotic drug inhibiting tubulin polymerization. Int. J. Cancer 107, 189-196 (2003).

    2. Cushman, M., Nagarathnam, D., Gopal, D., et al. Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. J. Med. Chem. 34, 2579-2588 (1991).

    3. Lin, H.S., and Ho, P.C. A rapid HPLC method for the quantification of 3,5,4'-trimethoxy-trans-stilbene (TMS) in rat plasma and its application in pharmacokinetic study. J. Pharm. Biomed. Anal. 49, 387-392 (2009).