Inhibitor of phospholipase D1 and D2
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Halopemide

Item No. 13205

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-ethyl]-4-fluoro-benzamide
CAS Number
59831-65-1
Synonyms
  • NSC 354856
  • R34301
Molecular Formula
C21H22ClFN4O2
Formula Weight
416.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 10 mg/ml
λmax
293 nm
SMILES
ClC1=CC2=C(N(C3CCN(CCNC(C4=CC=C(F)C=C4)=O)CC3)C(N2)=O)C=C1
InChi Code
InChI=1S/C21H22ClFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
InChi Key
NBHPRWLFLUBAIE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $143

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    10 mg

    $259

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    25 mg

    $587

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    Product Description

    Halopemide is a potent inhibitor of phospholipase D (PLD), inhibiting human PLD1 and PLD2 in vitro (IC50 = 220 and 310 nM, respectively) and PLD activity in cells.1 Previously, halopemide has been found to inhibit dopamine receptors and was evaluated as a neuroleptic agent.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Scott, S.A., Selvy, P.E., Buck, J.R., et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat. Chem. Biol. 5(2), 108-117 (2009).

    2. Seeman, P., Grigoriadis, D.E., and Niznik, H.B. Selectivity of agonists and antagonists at D2 dopamine receptors compared to D1 and S2 receptors. Drug Dev. Res. 9, 63-69 (1986).

    Product Citations

    Katsuma, S., Hatae, N., Yano, T., et al. Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. The Journal of Biological Chemisty 280(20), 19507-19515 (2005).