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VU0155069

Item № 13206
Purity ≥95%
product image
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $29.00 0.00
     5 mg $80.00 0.00
     10 mg $145.00 0.00
     25 mg $290.00 0.00

Pricing updated 2019-06-26. Prices are subject to change without notice.

Description
Synonyms
  • CAY10593

Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are regulated differently and apparently subserve distinct roles. VU0155069 is a potent and selective inhibitor of phospholipase D (PLD)1, both in vitro (IC50 = 46 nM) and in cells (IC50 = 11 nM).1 It is also effective as a PLD2 inhibitor at higher concentrations (IC50 = 933 nM in vitro; 1,800 nM in cells).1 VU0155069 strongly inhibits the invasive migration of several breast cancer cell lines in transwell assays, suggesting that PLD might be a useful target in blocking tumor cell invasion.1

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Technical Information
Formal Name
N-[2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-naphthalenecarboxamide
Synonyms
  • CAY10593
Molecular Formula
C26H27ClN4O2
Formula Weight
463.0
Purity
≥95%
Formulation
A crystalline solid
λmax
212, 232, 292 nm
SMILES
ClC1=CC2=C(N(C3CCN(CC(C)N([H])C(C4=CC(C=CC=C5)=C5C=C4)=O)CC3)C(N2[H])=O)C=C1
InChI Code
InChI=1S/C26H27ClN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)
InChI Key
DRIMIUYGTDAQOX-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Scott, S.A., Selvy, P.E., Buck, J.R., et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness Nature Chemical Biology 5(2), 108-117 (2009).

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