Small molecule inducer of neuronal differentiation
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Product Categories

Product Type

Biochemicals

Research Area

Neuroscience

Neurodazine

Item No. 13224

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[5-(3-chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
CAS Number
937807-66-4
Molecular Formula
C27H21ClN2O3
Formula Weight
456.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
λmax
277, 357 nm
SMILES
COc1ccc(cc1)c1[nH]c(nc1c1ccc(OC)cc1)c1ccc(o1)c1cccc(Cl)c1
InChi Code
InChI=1S/C27H21ClN2O3/c1-31-21-10-6-17(7-11-21)25-26(18-8-12-22(32-2)13-9-18)30-27(29-25)24-15-14-23(33-24)19-4-3-5-20(28)16-19/h3-16H,1-2H3,(H,29,30)
InChi Key
FEEOFPAEDSMOTO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $134

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    10 mg

    $169

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    25 mg

    $376

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    50 mg

    $667

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    Product Description

    Neurodazine induces neuronal differentiation in skeletal muscle cells.1 In mouse C2C12 myoblasts, neurodazine (2 μM for seven days) upregulated the expression of neuron-specific enolase (NSE), neurofilament 200 (NF200), synapsin, and other neuronal markers. Neurodazine similarly upregulated NSE and NF200 in human skeletal muscle fibers, indicating efficacy in mature muscle as well as in myoblasts.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wiliams, D.R., Lee, M.R., Song, Y.A., et al. Synthetic small molecules that induce neurogenesis in skeletal muscle. J. Am. Chem. Soc. 129(30), 9258-9259 (2007).