A potent and selective inhibitor of O-GlcNAcase
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Thiamet G

Item No. 13237

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
CAS Number
1009816-48-1
Molecular Formula
C9H16N2O4S
Formula Weight
248.3
Purity
≥97%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 0.5 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
[H][C@@]12[C@@](N=C(N(CC)[H])S2)([H])[C@@H](O)[C@H](O)[C@@H](CO)O1
InChi Code
InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1
InChi Key
PPAIMZHKIXDJRN-FMDGEEDCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $98

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    10 mg

    $147

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    Product Description

    Thiamet G is a potent and selective inhibitor of O-GlcNAcase that demonstrates a Ki value of 21 nM.1 It increases cellular O-GlcNAc-modified protein levels (EC50 = 30 nM) and blocks phosphorylation of tau protein both in cultured PC-12 cells and in rats (200 mg/kg/day).1 Thiamet G is the first highly potent O-GlcNAcase inhibitor known to be orally bioavailable and effectively cross the blood brain barrier.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yuzwa, S.A., Macauley, M.S., Heinonen, J.E., et al. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat. Chem. Biol. 4(8), 483-490 (2008).