Fluorogenic substrate of S1P lyase
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Sphingosine-1-Phosphate Lyase Fluorogenic Substrate

Item No. 13238

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2S-ammonio-3R-hydroxy-5-((2-oxo-2H-chromen-7-yl)oxy)pentyl hydrogen phosphate
CAS Number
1166838-84-1
Synonyms
  • RBM13
  • S1P Lyase Fluorogenic Substrate
Molecular Formula
C14H18NO8P
Formula Weight
359.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
10 Mm NaOH: 1 mg/mlDMF: 0.5 mg/mlDMSO: 0.5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
324 nm
SMILES
O=C1OC2=C(C=CC(OCC[C@@H](O)[C@@H]([NH3+])COP([O-])(O)=O)=C2)C=C1
InChi Code
InChI=1S/C14H18NO8P/c15-11(8-22-24(18,19)20)12(16)5-6-21-10-3-1-9-2-4-14(17)23-13(9)7-10/h1-4,7,11-12,16H,5-6,8,15H2,(H2,18,19,20)/t11-,12+/m0/s1
InChi Key
XHAKPJBOPPIZOR-NWDGAFQWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $225

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    1 mg

    $382

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    5 mg

    $1,683

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    Product Description

    S1P lyase fluorogenic substrate is a substrate of S1P lyase, leading to the production of the fluorescent product umbelliferone (7-hydroxycoumarin) under appropriate conditions.1 This compound is intended to be used to monitor or measure S1P lyase activity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bedia, C., Camacho, L., Casas, J., et al. Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. Chembiochem 10(5), 820-822 (2009).

    Product Citations

    Pitman, M., Lewis, A.C., Davies, L.T., et al. The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism. Sci. Rep. 12(1), 454 (2022).