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(−)-AS 115

Item № 13250
CAS № 926657-43-4
Purity ≥98%
product image
                (CAS 926657-43-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     100 µg $47.00 0.00
     500 µg $212.00 0.00
     1 mg $376.00 0.00

Pricing updated 2019-05-26. Prices are subject to change without notice.

Description

KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues.1 The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network.2 AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SKOV3.2 Treatment of SKOV3 cells with 10 µM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e. (+)-AS 115 and (−)-AS 115, has not been determined.

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Technical Information
Formal Name
2-fluorophenyl-(2-(((1R,2S)-2-(butoxymethyl)cyclohexyl)methoxy)ethyl)carbamate
CAS Number
926657-43-4
Molecular Formula
C21H32FNO4
Formula Weight
381.5
Purity
≥98%
Formulation
A solution in methyl acetate
λmax
205, 261, 267 nm
SMILES
O=C(OC1=CC=CC=C1F)NCCOC[C@H]2[C@@H](COCCCC)CCCC2
InChI Code
InChI=1S/C21H32FNO4/c1-2-3-13-25-15-17-8-4-5-9-18(17)16-26-14-12-23-21(24)27-20-11-7-6-10-19(20)22/h6-7,10-11,17-18H,2-5,8-9,12-16H2,1H3,(H,23,24)/t17-,18+/m1/s1
InChI Key
BTYYXSHZANWPEB-MSOLQXFVSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 1 year
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Jessani, N., Liu, Y., Humphrey, M., et al. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness Proceedings of the National Academy of Sciences of the United States of America 99(16), 10335-10340 (2002).

2. Chiang, K.P., Niessen, S., Saghatelian, A., et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling Chemistry & Biology 13, 1041-1050 (2006).

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