A biotinylated spin trap
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DEPMPO-biotin

Item No. 13251

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]propyl]-[(2S,3R)-2-(diethoxyphosphinyl)-3,4-dihydro-2-methyl-1-oxido-2H-pyrrol-3-yl]methyl ester-carbamic acid
CAS Number
936224-52-1
Molecular Formula
C24H42N5O8PS
Formula Weight
591.7
Purity
≥95%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 10 mg/mlWater: 1 mg/ml
λmax
202, 241 nm
SMILES
CCOP(=O)(OCC)C1(C)[C@H](COC(=O)NCCCNC(=O)CCCC[C@H]2SC[C@H]3NC(=O)N[C@@H]23)CC=[N+]1[O-]
InChi Code
InChI=1S/C24H42N5O8PS/c1-4-36-38(34,37-5-2)24(3)17(11-14-29(24)33)15-35-23(32)26-13-8-12-25-20(30)10-7-6-9-19-21-18(16-39-19)27-22(31)28-21/h14,17-19,21H,4-13,15-16H2,1-3H3,(H,25,30)(H,26,32)(H2,27,28,31)/t17-,18+,19-,21+,24?/m0/s1
InChi Key
UAQUUBGIOJZAFO-GLZOQUOBSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $118

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    50 µg

    $219

    Add

    100 µg

    $416

    Add

    250 µg

    $920

    Add
    Product Description

    DEPMPO-biotin is a biotinylated form of DEPMPO which retains the outstanding persistency of its adducts.1 The biotin moiety offers an effective means for monitoring biodistribution in cells, tissues, and organs when used with an avidin-conjugated reporter. Importantly, DEPMPO-biotin binds free radicals, such as S-nitroso groups, on proteins, producing adducts that can be analyzed via the biotin tag. This direct labeling of S-nitrosothiols (SNO) thus serves as an effective alternative to the more cumbersome biotin-switch method for monitoring SNO formation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chalier, F., Hardy, M., Ouari, O., et al. Design of new derivatives of nitrone DEPMPO functionalized at C-4 for further specific applications in superoxide radical detection. The Journal of Organic Chemistry 72, 7886-7892 (2007).