A RyR1-FKBP12 protein-protein interaction stabilizer
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

S107

Item No. 13253

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,4,5-tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine
CAS Number
927871-76-9
Molecular Formula
C11H15NOS
Formula Weight
209.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 0.5 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
258, 292 nm
SMILES
COC1=CC=C(SCCN(C)C2)C2=C1
InChi Code
InChI=1S/C11H15NOS/c1-12-5-6-14-11-4-3-10(13-2)7-9(11)8-12/h3-4,7H,5-6,8H2,1-2H3
InChi Key
BGVCEGVSQDOGSB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $90

    Add

    10 mg

    $169

    Add

    25 mg

    $401

    Add

    50 mg

    $622

    Add
    Product Description

    S107 is a stabilizer of the protein-protein interaction between ryanodine receptor 1 (RyR1) and FK-506 binding protein 1A (FKBP12).1,2 It stabilizes sarcoplasmic reticulum RyR1 channels by decreasing the dissociation of FKBP12 in isolated mouse muscle fibers.2 S107 (50 and 100 µM) also reduces neurite growth and length in isolated spinal cords from neonatal rats.3 Ex vivo, S107 reduces exercise-induced calcium leakage in mouse muscle fibers.1 S107 decreases muscle fatigue and increases treadmill running time in mice. It increases grip strength and reduces exercise-induced muscle damage in a dystrophin DMD-/- knockout mouse model of Duchenne muscular dystrophy.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bellinger, A.M., Reiken, S., Dura, M., et al. Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity. Proc. Natl. Acad. Sci. USA 105(6), 2198-2202 (2008).

    2. Bellinger, A.M., Reiken, S., Carlson, C., et al. Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat. Med. 15(3), 325-330 (2009).

    3. Keilhoff, G., Pinkernelle, J., and Fansa, H. The Ryanodine receptor stabilizer S107 fails to support motor neuronal neuritogenesis in vitro. Tissue Cell 73, 101625 (2021).

    Product Citations

    Keilhoff, G., Pinkernelle, J., and Fansa, H. The Ryanodine receptor stabilizer S107 fails to support motor neuronal neuritogenesis in vitro. Tissue Cell 73, 101625 (2021).