A 5-LO inhibitor
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AA-861

Item No. 13263

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(12-hydroxy-5,10-dodecadiyn-1-yl)-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione
CAS Number
80809-81-0
Synonyms
  • A-61589
  • Docebenone
Molecular Formula
C21H26O3
Formula Weight
326.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 250 mg/ml, sonicated
SMILES
CC1=C(C)C(C(CCCCC#CCCCC#CCO)=C(C)C1=O)=O
InChi Code
InChI=1S/C21H26O3/c1-16-17(2)21(24)19(18(3)20(16)23)14-12-10-8-6-4-5-7-9-11-13-15-22/h22H,5,7-10,12,14-15H2,1-3H3
InChi Key
WDEABJKSGGRCQA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $183

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    1 mg

    $345

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    Product Description

    AA-861 is an inhibitor of 5-lipoxygenase (5-LO; IC50 = 0.8 µM).1 It is greater than 100-fold selective for 5-LO over 12-LO and cyclooxygenase (COX). AA-861 inhibits the production of 5-HETE and leukotriene B4 (LTB4; Item No. 20110) induced by A23187 (Item No. 22030) with IC50 values of 0.03 and 0.08 µM, respectively, in isolated rat peritoneal macrophages.2 It reduces paw edema, pleurisy, and cell infiltration induced by carrageenan in rats when administered at a dose of 80 mg/kg. AA-861 (20 mg/kg) reduces ovalbumin-induced bronchoconstriction in an ovalbumin-sensitized guinea pig model of experimental allergic asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoshimoto, T., Yokoyama, C., Ochi, K., et al. 2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-l,4-benzoquinone (AA861), a selective inhibitor of the 5-lipoxygenase reaction and the biosynthesis of slow-reacting substance of anaphylaxis. Biochim. Biophys. Acta 713(2), 470-473 (1982).

    2. Ashida, Y., Saijo, T., Kuriki, H., et al. Pharmacological profile of AA-861, a 5-lipoxygenase inhibitor. Prostaglandins 26(6), 955-972 (1983).