An isoprenoid with diverse biological activities
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Farnesyl Alcohol

Item No. 13268

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,7,11-trimethyl-2,6,10-dodecatrien-1-ol
CAS Number
4602-84-0
Synonyms
  • Farnesol
  • FCI 119a
  • NSC 60597
Molecular Formula
C15H26O
Formula Weight
222.4
Purity
≥98% (mixture of isomers)
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
OC/C=C(CC/C=C(CC/C=C(C)\C)\C)\C
InChi Code
InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3/b14-9+,15-11+
InChi Key
CRDAMVZIKSXKFV-YFVJMOTDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $86

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    50 mg

    $163

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    Product Description

    Farnesyl alcohol is an isoprenoid that has been found in aromatic plants and has diverse biological activities.1,2,3,4 It is an agonist of peroxisome proliferator-activator receptor α (PPARα) and PPARγ (EC50s = 5.5 and 28 µM, respectively, in a reporter assay using CV-1 cells) and increases the expression of mRNA encoding the PPARα targets carnitine palmitoyltransferase 1 (CPT1) and acetyl-CoA synthetase (ACS) in HepG2 cells when used at a concentration of 100 µM.1 Farnesyl alcohol (250 µM) is a fungal quorum-sensing molecule and inhibits the yeast-to-mycelium conversion in C. albicans.2 It decreases the severity of oral candidiasis induced by C. albicans, but does not reduce C. albicans viability or the number of colony forming units (CFUs), in mice immunosuppressed by prednisolone (Item No. 20866) when administered at doses of 1.125, 2.25, and 9 µmol/animal.3 Farnesyl alcohol (0.02-0.1 mg/cm2) repels S. medanensis mites and is toxic to those same mites in a contact assay (LC50 = 0.048 mg/cm2 per vial).4 Formulations containing farnesyl alcohol have been used as pesticides in agriculture.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takahashi, N., Kawada, T., Goto, T., et al. Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3-L1 adipocytes and HepG2 hepatocytes. FEBS Lett. 514(2-3), 315-322 (2002).

    2. Hornby, J.M., Jensen, E.C., Lisec, A.D., et al. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl. Environ. Microbiol. 67(7), 2982-2992 (2001).

    3. Hisajima, T., Maruyama, N., Tanabe, Y., et al. Protective effects of farnesol against oral candidiasis in mice. Microbiol. Immunol. 52(7), 327-333 (2008).

    4. Bakr, A.A., Saad, M.M.G., and Abdelgaleil, A.M. Mite incidence in Egyptian storage facilities and acaricidal activity of selected monoterpenes, phenylpropenes, and sesquiterpenes against Suidasia medanensis Oudemans (Astigmata: Suidasiidae), a formidable storage mite pest. Persian J. Acarol. 11(1), 101–113 (2022).