An HDAC inhibitor
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Isomer(s)
30607AES-350
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(S)-HDAC-42

Item No. 13277

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[(hydroxyamino)carbonyl]phenyl]-αS-(1-methylethyl)-benzeneacetamide
CAS Number
935881-37-1
Synonyms
  • AR42
  • OSU-HDAC 42
Molecular Formula
C18H20N2O3
Formula Weight
312.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
SMILES
O=C(NC1=CC=C(C(NO)=O)C=C1)[C@@H]([C@H](C)C)C2=CC=CC=C2
InChi Code
InChI=1S/C18H20N2O3/c1-12(2)16(13-6-4-3-5-7-13)18(22)19-15-10-8-14(9-11-15)17(21)20-23/h3-12,16,23H,1-2H3,(H,19,22)(H,20,21)/t16-/m0/s1
InChi Key
LAMIXXKAWNLXOC-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Product Description

    (S)-HDAC-42 is a histone deacetylase (HDAC) inhibitor (IC50 = 16 nM).1 It increases acetylation of histone H3 in DU145 prostate cancer cells when used at concentrations ranging from 0.1 to 2.5 µM. (S)-HDAC-42 decreases viability of DU145 cells (IC50 = 0.11 µM). It induces cell cycle arrest at the G1 phase in A2780 ovarian cancer cells when used at a concentration of 0.5 µM.2 (S)-HDAC-42 (25 mg/kg per day or 50 mg/kg every other day) decreases tumor volume in a PC3 prostate cancer mouse xenograft model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lu, Q., Wang, D.S., Chen, C.S., et al. Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J. Med. Chem. 48(17), 5530-5535 (2005).

    2. Yang, Y.-T., Balch, C., Kulp, S.K., et al. A rationally designed histone deacetylase inhibitor with distinct antitumor activity against ovarian cancer. Neoplasia 11(6), 552-563 (2009).

    3. Kulp, S.K., Chen, C.S., Wang, D.S., et al. Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer. Clin. Cancer Res. 12(17), 5199-5206 (2006).