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Item № 13282
CAS № 1143573-33-4
Purity ≥98%
product image
                (CAS 1143573-33-4)
     1 mg $46.00 0.00
     5 mg $207.00 0.00
     10 mg $368.00 0.00
     25 mg $805.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.


Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo.1,2 The prototypical compound for this class is the TZD rosiglitazone (BRL 49653), which is currently marketed for the treatment of diabetes. CAY10599 is a PPARγ agonist that is 4-fold more potent than rosiglitazone at the PPARγ receptor demonstrating an EC50 value of 0.05 µM.3 This compound shows high selectivity for PPARγ over PPARα (EC50 = 3.99 µM) or PPARδ (EC50 > 10 µM).3

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Technical Information
Formal Name
2-[[1-[3-[4-([1,1'-biphenyl]-4-ylcarbonyl)-2-propylphenoxy]propyl]-1,2,3,4-tetrahydro-5-quinolinyl]oxy]-2-methyl-propanoic acid
CAS Number
Molecular Formula
Formula Weight
A crystalline solid
299 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Willson, T.M., Cobb, J.E., Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones J. Med. Chem. 39, 665-668 (1996).

2. Cantello, B.C.C., Cawthorne, M.A., Cottam, G.P., et al. [[ω-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents J. Med. Chem. 37, 3977-3985 (1994).

3. Lin, C.H., Peng, Y.H., Coumar, M.S., et al. Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor g agonists Journal of Medicinal Chemistry 52, 2618-2622 (2009).

Product Citations

Change, Y.-C., Chen, Y.-J., Huang, C.-W., et al. Cyclic stretch facilitates myogenesis in C2C12 myoblasts and rescues thiazolidinedione-inhibited myotube formation Front. Bioeng. Biotechnol. 4(27), (2016).

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