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CAY10599

Item № 13282
CAS № 1143573-33-4
Purity ≥98%
product image
                (CAS 1143573-33-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $46.00 0.00
     5 mg $207.00 0.00
     10 mg $368.00 0.00
     25 mg $805.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description

Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo.1,2 The prototypical compound for this class is the TZD rosiglitazone (BRL 49653), which is currently marketed for the treatment of diabetes. CAY10599 is a PPARγ agonist that is 4-fold more potent than rosiglitazone at the PPARγ receptor demonstrating an EC50 value of 0.05 µM.3 This compound shows high selectivity for PPARγ over PPARα (EC50 = 3.99 µM) or PPARδ (EC50 > 10 µM).3

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Technical Information
Formal Name
2-[[1-[3-[4-([1,1'-biphenyl]-4-ylcarbonyl)-2-propylphenoxy]propyl]-1,2,3,4-tetrahydro-5-quinolinyl]oxy]-2-methyl-propanoic acid
CAS Number
1143573-33-4
Molecular Formula
C38H41NO5
Formula Weight
591.7
Purity
≥98%
Formulation
A crystalline solid
λmax
299 nm
SMILES
CC(C)(C(O)=O)OC1=CC=CC2=C1CCCN2CCCOC3=CC=C(C(C4=CC=C(C5=CC=CC=C5)C=C4)=O)C=C3CCC
InChI Code
InChI=1S/C38H41NO5/c1-4-11-30-26-31(36(40)29-19-17-28(18-20-29)27-12-6-5-7-13-27)21-22-34(30)43-25-10-24-39-23-9-14-32-33(39)15-8-16-35(32)44-38(2,3)37(41)42/h5-8,12-13,15-22,26H,4,9-11,14,23-25H2,1-3H3,(H,41,42)
InChI Key
JWJGBYOYIUOQEB-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Willson, T.M., Cobb, J.E., Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones J. Med. Chem. 39, 665-668 (1996).

2. Cantello, B.C.C., Cawthorne, M.A., Cottam, G.P., et al. [[ω-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents J. Med. Chem. 37, 3977-3985 (1994).

3. Lin, C.H., Peng, Y.H., Coumar, M.S., et al. Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor g agonists Journal of Medicinal Chemistry 52, 2618-2622 (2009).

Product Citations

Change, Y.-C., Chen, Y.-J., Huang, C.-W., et al. Cyclic stretch facilitates myogenesis in C2C12 myoblasts and rescues thiazolidinedione-inhibited myotube formation Front. Bioeng. Biotechnol. 4(27), (2016).

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