An agonist of PPARγ
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CAY10599

Item No. 13282

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[1-[3-[4-([1,1'-biphenyl]-4-ylcarbonyl)-2-propylphenoxy]propyl]-1,2,3,4-tetrahydro-5-quinolinyl]oxy]-2-methyl-propanoic acid
CAS Number
1143573-33-4
Molecular Formula
C38H41NO5
Formula Weight
591.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/ml
λmax
299 nm
SMILES
CC(C)(C(O)=O)OC1=CC=CC2=C1CCCN2CCCOC3=CC=C(C(C4=CC=C(C5=CC=CC=C5)C=C4)=O)C=C3CCC
InChi Code
InChI=1S/C38H41NO5/c1-4-11-30-26-31(36(40)29-19-17-28(18-20-29)27-12-6-5-7-13-27)21-22-34(30)43-25-10-24-39-23-9-14-32-33(39)15-8-16-35(32)44-38(2,3)37(41)42/h5-8,12-13,15-22,26H,4,9-11,14,23-25H2,1-3H3,(H,41,42)
InChi Key
JWJGBYOYIUOQEB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $49

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    1 mg

    $69

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    5 mg

    $306

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    10 mg

    $561

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    Product Description

    CAY10599 is an agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50 = 0.05 µM in a transactivation assay).1 It is selective for PPARγ over PPARα and PPARδ (EC50s = 3.99 and >10 µM, respectively, in transactivation assays).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, C.-H., Peng, Y.-H., Coumar, M.S., et al. Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor γ agonists. J. Med. Chem. 52(8), 2618-2622 (2009).

    Product Citations

    Change, Y.-C., Chen, Y.-J., Huang, C.-W., et al. Cyclic stretch facilitates myogenesis in C2C12 myoblasts and rescues thiazolidinedione-inhibited myotube formation. Front. Bioeng. Biotechnol. 4(27), (2016).