Pro-apoptotic analog of resveratrol
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Product Categories

Product Type

Biochemicals
Antioxidants

Research Area

Cancer
Cell Death
Apoptosis

CAY10616

Item No. 13291

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(1Z)-2-(3,5-dimethoxyphenyl)ethenyl]-2-methoxy-phenol
CAS Number
586410-08-4
Molecular Formula
C17H18O4
Formula Weight
286.3
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 14 mg/mlEthanol: 10 mg/ml
λmax
291 nm
SMILES
COc1cc(\C=C\c2ccc(OC)c(O)c2)cc(OC)c1
InChi Code
InChI=1S/C17H18O4/c1-19-14-8-13(9-15(11-14)20-2)5-4-12-6-7-17(21-3)16(18)10-12/h4-11,18H,1-3H3/b5-4-
InChi Key
UQIWTPQGJCCTPA-PLNGDYQASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $31

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    5 mg

    $129

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    10 mg

    $228

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    25 mg

    $493

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    Cayman Chemical
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    Product Description

    Resveratrol is a natural polyphenolic antioxidant that has anti-cancer properties. CAY10616 is an analog of resveratrol which potently induces apoptosis in promyelocytic leukemia HL-60 cells (IC50 = 40 nM, vs. 50 μM for resveratrol).1 In addition, CAY10599 induces apoptosis (IC50 = 30 nM) in HL-60R, a cell line derived from HL-60 that expresses a multidrug-resistance phenotype (resistant to daunorubicin, etoposide, and citarabine).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roberti, M., Pizzirani, D., Simoni, D., et al. Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. J. Med. Chem. 46(16), 3546-3554 (2003).