A potent, nonspecific kinase inhibitor
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H-9 (hydrochloride)

Item No. 13312

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-aminoethyl)-5-isoquinolinesulfonamide, dihydrochloride
CAS Number
116700-36-8
Synonyms
  • Protein Kinase Inhibitor H-9
Molecular Formula
C11H13N3O2S • 2HCl
Formula Weight
324.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1.5 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
217 nm
SMILES
NCCNS(=O)(=O)c1cccc2cnccc12
InChi Code
InChI=1S/C11H13N3O2S/c12-5-7-14-17(15,16)11-3-1-2-9-8-13-6-4-10(9)11/h1-4,6,8,14H,5,7,12H2
InChi Key
DCVZSHVZGVWQKV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $31

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    10 mg

    $55

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    25 mg

    $129

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    50 mg

    $228

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    Product Description

    The H series isoquinolinesulfonamide protein kinase inhibitors are widely used to block signaling pathways in order to elucidate mechanisms of cellular regulation and signal transduction. H-9, an isoquinolinesulfonamide protein kinase inhibitor, is a competitive inhibitor of PKC, PKG, and PKA with Ki values of 18, 0.87, and 1.9 µM, respectively.1 H-9 has been used to reduce the cAMP-mediated excitatory response to serotonin in C. elegans enteric neurons and to inhibit PKA-mediated phosphorylation in a rat seizure model.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hidaka, H., Inagaki, M., Kawamoto, S., et al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23(21), 5036-5041 (1984).

    2. Papaioannou, S., Holden-Dye, L., and Walker, R.J. Evidence for a role for cyclic AMP in modulating the action of 5-HT and an excitatory neuropeptide, FLP17A, in the pharyngeal muscle of Caenorhabditis elegans. Invert. Neurosci. 8(2), 91-100 (2008).

    3. Vázquez-López, A., Sierra-Paredes, G., and Sierra-Marcuño, G. Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures. Neurochem. Res. 30(5), 613-618 (2005).