A free radical scavenger
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MCI-186

Item No. 13320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
CAS Number
89-25-8
Synonyms
  • Edaravone
  • NSC 2629
Molecular Formula
C10H10N2O
Formula Weight
174.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 30 mg/mlEthanol: 15 mg/ml
λmax
244 nm
SMILES
O=C(CC(C)=N1)N1C2=CC=CC=C2
InChi Code
InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
InChi Key
QELUYTUMUWHWMC-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    MCI-186 is a free radical scavenger with diverse protective effects in vivo. Most notably, it reduces damage due to ischemia-reperfusion injury in lung, liver, and brain in animal models of transplant, infection, traumatic brain injury, and stroke.1,2,3,4 MCI-186 provides these protective effects, at least in part, by reducing reactive oxygen species, inhibiting apoptosis, and blocking nonenzymatic peroxidation and lipoxygenase activity.3,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, J.z., Shen, B.z., Li, Y., et al. Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model. Chin. Med. J. (Engl.) 121(16), 1583-1587 (2008).

    2. Kono, H., Asakawa, M., Fujii, H., et al. Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J. Pharmacol. Exp. Ther. 307(1), 74-82 (2003).

    3. Gao, Y., Ding, X.s., Xu, S., et al. Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage. Chin. Med. J. (Engl.) 122(16), 1935-1940 (2009).

    4. Kikuchi, K., Kawahara, K.i., Tancharoen, S., et al. The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. J. Pharmacol. Exp. Ther. 329(3), 865-874 (2009).

    5. Rajesh, K.G., Sasaguri, S., Suzuki, R., et al. Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am. J. Physiol. Heart Circ. Physiol. 285, H2171-H2178 (2003).

    6. Abe, K., Yuki, S., and Kogure, K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19, 480-485 (1988).