An inactivator of p53
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Pifithrin-α

Item No. 13326

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-ethanone, monohydrobromide
CAS Number
63208-82-2
Synonyms
  • PFT-α
Molecular Formula
C16H18N2OS • HBr
Formula Weight
367.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
λmax
259 nm
SMILES
N=C(S1)N(CC(C2=CC=C(C)C=C2)=O)C3=C1CCCC3.Br
InChi Code
InChI=1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H
InChi Key
HAGVCKULCLQGRF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.1 It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 μM 1 and in human umbilical vein endothelial cells at 30 μM.2 Pifithrin-α can also protect cells from DNA damage-induced apoptosis by a p53-independent mechanism that might involve cyclin D1.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Komarov, P.G., Komarova, E.A., Kondratov, R.V., et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285(5434), 1733-1737 (1999).

    2. Lorenzo, E., Ruiz-Ruiz, C., Quesada, A.J., et al. Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. The Journal of Biological Chemisty 277(17), 10883-10892 (2002).

    3. Sohn, D., Graupner, V., Neise, D., et al. Pifithrin-α protects against DNA damage-inducedapoptosis downstream of mitochondria independentof p53. Cell Death Differ. 16, 869-878 (2009).