An adenylyl cyclase inhibitor
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SQ 22,536

Item No. 13339

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-(tetrahydro-2-furanyl)-9H-purin-6-amine
CAS Number
17318-31-9
Synonyms
  • NSC 53339
Molecular Formula
C9H11N5O
Formula Weight
205.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
209, 260 nm
SMILES
NC1=C2C(N(C3OCCC3)C=N2)=NC=N1
InChi Code
InChI=1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)
InChi Key
UKHMZCMKHPHFOT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $127

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    25 mg

    $297

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    50 mg

    $525

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    Product Description

    SQ 22,536 is an inhibitor of adenylyl cyclase with an IC50 value of 13 μM for inhibition of prostaglandin E1-stimulated increase in cAMP in intact platelets.1 It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research paradigms, inhibiting cAMP elevation at concentrations of 100-300 μM without effecting relaxation.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haslam, R.J., Davidson, M.M.L., and Desjardins, J.V. Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Biochem. J. 176(1), 83-95 (1978).

    2. Turcato, S., and Clapp, L.H. Effects of the adenylyl cyclase inhibitor SQ22536 on iloprost-induced vasorelaxation and cyclic AMP elevation in isolated guinea-pig aorta. Br. J. Pharmacol. 126(4), 845-847 (1999).

    3. Gao, Y., and Raj, J.U. Effects of SQ 22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cyclic AMP elevation and relaxation in newborn ovine pulmonary veins. Eur. J. Pharmacol. 436(3), 227-233 (2002).