Pricing updated 2018-02-18. Prices are subject to change without notice.
As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions.1 Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in zinc treatment studies to limit intra-
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1. Beyersmann, D., and Haase, H. Functions of zinc in signaling, proliferation and differentiation of mammalian cells. BioMetals 14, 331-341 (2001).
Cho, Y.E.,Lomeda, R.A.R.,Ryu, S.H., et al. Cellular Zn depletion by metal ion chelators (TPEN, DTPA and chelex resin) and its application to osteoblastic MC3T3-
Makhov, P.,Golovine, K.,Uzoo, R.G., et al. Zinc chelation induces rapid depletion of the X-
4. Bernal, P.J.,Leelavanichkul, K.,Bauer, E., et al. Nitric oxide mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone. Circulation Research 102(12), 1575-1583 (2008).