A water-soluble, slow-releasing H2S donor
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GYY 4137

Item No. 13345

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(p-methoxyphenyl)morpholino-phosphinodithioic acid
CAS Number
106740-09-4
Molecular Formula
C11H16NO2PS2 • C4H10NO
Formula Weight
377.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 15 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
COc1ccc(cc1)P(=S)([S-])N1CCOCC1.C1COCC[NH2+]1
InChi Code
InChI=1S/C11H16NO2PS2.C4H9NO/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12;1-3-6-4-2-5-1/h2-5H,6-9H2,1H3,(H,16,17);5H,1-4H2
InChi Key
YZMHNNLDUWRZFW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $68

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    25 mg

    $154

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    50 mg

    $258

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    100 mg

    $481

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    Product Description

    Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor.1 When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models.1 Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, L., Whiteman, M., Guan, Y.Y., et al. Characterization of a novel, water-soluble hydrogen sulfide releasing molecule (GYY4137): New insights into the biology of hydrogen sulfide. Circulation 117(18), 2351-2360 (2008).

    2. Li, L., Salto-Tellez, M., Tan, C.H., et al. GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Free Radic. Biol. Med. 47(1), 103-113 (2009).

    Product Citations

    Liguori, A., Petri, E., Gualandi, C., et al. Controlled release of H2S from biomimetic silk fibroin-PLGA multilayer electrospun scaffolds. Biomacromolecules 24(3), 1366-1376 (2023).