Non-specific inhibitor of cAMP and cGMP phosphodiesterases
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IBMX

Item No. 13347

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,9-dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
CAS Number
28822-58-4
Synonyms
  • Isobutylmethylxanthine
  • 1-Methyl-3-Isobutylxanthine
  • NSC 165960
  • SC-2964
Molecular Formula
C10H14N4O2
Formula Weight
222.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
272 nm
SMILES
CC(C)CN(C1=C2NC=N1)C(N(C)C2=O)=O
InChi Code
InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
InChi Key
APIXJSLKIYYUKG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $43

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    250 mg

    $81

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    500 mg

    $140

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    1 g

    $237

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    Product Description

    IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX.1 By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fawcett, L., Baxendale, R., Stacey, P., et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc. Natl. Acad. Sci. USA 97(7), 3702-3707 (2000).

    2. Snyder, S.H., Katims, J.J., Annau, Z., et al. Adenosine receptors and behavioral actions of methylxanthines. Proc. Natl. Acad. Sci. USA 78(5), 3260-3264 (1981).

    Product Citations

    Matsumoto, N., Singh, N., Lee, K.S., et al. The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms. Prostaglandins Other Lipid Mediat. 162, 106662 (2022).