An expected urinary metabolite of PGD2
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tetranor-PGJM

Item No. 13363

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-((1R,2S)-2-(2-carboxyethyl)-5-oxocyclopent-3-en-1-yl)-6-oxooctanoic acid
CAS Number
1352751-83-7
Synonyms
  • tetranor-PGJ Metabolite
Molecular Formula
C16H22O6
Formula Weight
310.3
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
219 nm
SMILES
O=C1C=C[C@H](CCC(O)=O)[C@H]1CCC(CCCCC(O)=O)=O
InChi Code
InChI=1S/C16H22O6/c17-12(3-1-2-4-15(19)20)7-8-13-11(5-9-14(13)18)6-10-16(21)22/h5,9,11,13H,1-4,6-8,10H2,(H,19,20)(H,21,22)/t11-,13-/m1/s1
InChi Key
KPFBKANRLYZJQP-DGCLKSJQSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $161

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    50 µg

    $306

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    100 µg

    $578

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    Product Description

    Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.1 tetranor-PGDM is an abundant urinary metabolite of PGD2 that is detectable both in human and mouse and, as such, is used as a biomarker of PGD2 biosynthesis.2 tetranor-PGJM is a potential PGD2 metabolite, formed by the elimination of the C-9 hydroxyl group. This compound may serve as a useful control in the analysis of PGD2 biosynthesis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35(2), 277-300 (1988).

    2. Song, W.L., Wang, M., Ricciotti, E., et al. Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. The Journal of Biological Chemisty 283(2), 1179-1188 (2008).