An inhibitor of bacterial FtsZ
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PC190723

Item No. 13518

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy]-2,6-difluoro-benzamide
CAS Number
951120-33-5
Molecular Formula
C14H8ClF2N3O2S
Formula Weight
355.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10mg/ml
λmax
218, 298 nm
SMILES
FC1=C(OCC2=NC(C=C(Cl)C=N3)=C3S2)C=CC(F)=C1C(N)=O
InChi Code
InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21)
InChi Key
INYJNSBDHOVLAH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $87

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    5 mg

    $261

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    10 mg

    $479

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    25 mg

    $1,087

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    Cayman Chemical
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    Product Description

    PC190723 is an inhibitor of bacterial FtsZ, a homolog of mammalian β-tubulin.1 It is active against B. subtilis, S. epidermidis, S. hemolyticus, and S. aureus, including methicillin-resistant S. aureus (MRSA) and multidrug-resistant S. aureus (MDRSA; MICs = 0.5-1 µg/ml). PC190723 (10 and 30 mg/kg) increases survival in a mouse model of lethal S. aureus infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Auwärter, V., Dresen, S., Weinmann, W., et al. “Spice” and other herbal blends: Harmless incense or cannabinoid designer drugs? J. Mass Spectrom. 44(5), 832-837 (2009).