Compound from Chinese traditional medicine with reported antifungal, anticancer actions
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Pseudolaric Acid B

Item No. 13527

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,4S,4aS,9aR)-4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-1H-4,9a-ethanocyclohepta[c]pyran-7-carboxylic acid, 7-methyl ester
CAS Number
82508-31-4
Synonyms
  • NSC 615488
  • PAB
Molecular Formula
C23H28O8
Formula Weight
432.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
258 nm
SMILES
O=C1[C@@]23[C@@](CCC(C(OC)=O)=CC2)(OC(C)=O)[C@](CC3)([H])[C@](/C=C/C=C(C)/C(O)=O)(C)O1
InChi Code
InChI=1S/C23H28O8/c1-14(18(25)26)6-5-10-21(3)17-9-12-22(20(28)31-21)11-7-16(19(27)29-4)8-13-23(17,22)30-15(2)24/h5-7,10,17H,8-9,11-13H2,1-4H3,(H,25,26)/b10-5+,14-6+/t17-,21+,22+,23-/m0/s1
InChi Key
VDGOFNMYZYBUDT-YDRCMHEVSA-N
Origin
Plant/Pseudolarix amabilis (J. Nelson) Rehd.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

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    Product Description

    Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities, consistent with its traditional use in the treatment of dermatological fungal infections.1 Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, E., Clark, A.M., and Hufford, C.D. Antifungal evaluation of pseudolaric acid B, a major constituent of Pseudolarix kaempferi. J. Nat. Prod. 58(1), 57-67 (1995).

    2. Gong, X., Wang, M., Tashiro, S.i., et al. Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death. Exp. Mol. Med. 38(4), 428-434 (2006).

    3. Wong, V.K.W., Chiu, P., Chung, S.S.M., et al. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo. Clin. Cancer Res. 11(16), 6002-6011 (2005).

    4. Li, M.H., Miao, Z.H., Tan, W.F., et al. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1α by promoting proteasome-mediated degradation. Clin. Cancer Res. 10(24), 8266-8274 (2004).