For immunochemical analysis of PARP
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PARP (Cleaved) Monoclonal Antibody

Item No. 13557

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Immunogen
synthetic peptide containing amino acids near the 214/215 cleavage site of human PARP
Formulation (Request formulation change)
100 µg protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
Host
Mouse
Isotype
IgG2bκ
Applications
WB and FC (intracellular)
Species Reactivity
(+) Human PARP
Origin
Animal/Mouse
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 ea

    $395

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    Product Description

    The poly(ADP-ribose) polymerase (PARP) is involved in cell recovery from DNA damage, such as methylation of N3-adenine, which activates the base excision repair process. PARP is a 116 kDa nuclear chromatin-associated enzyme that is cleaved during apoptosis by caspase-3 into a 24 kDa fragment containing the DNA binding domain and an 89 kDa fragment containing the catalytic and automodification domains. The 24 kDa fragment irreversibly binds to DNA and may contribute to the irreversibility of apoptosis by blocking the access of DNA repair enzymes to DNA strand breaks.

    WARNING This product is not for human or veterinary use.